Airway remodeling in asthma: therapeutic implications of mechanisms.
نویسندگان
چکیده
Asthma is currently recognized as a chronic inflammatory disorder of the airways that leads to tissue injury and subsequent structural changes collectively called airway remodeling. Transgenic modeling of inflammatory mediators allows for the discovery of unexpected effects, dissection of downstream signaling events, and clues to future therapies.
منابع مشابه
Mechanisms of Remodeling in Asthmatic Airways
Asthma is a chronic inflammatory airway disorder characterized by airway hyperresponsiveness and reversible airflow obstruction. Subgroups of asthma patients develop airflow obstruction that is irreversible or only partially reversible and experience an accelerated rate of lung function decline. The structural changes in the airways of these patients are referred to as airway remodeling. All el...
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عنوان ژورنال:
- Physiology
دوره 20 شماره
صفحات -
تاریخ انتشار 2005